ADME Services 


PHARMout offers ADME (Absorption, Distribution, Metabolism, Excretion) services to provide fast and improved decision making for our clients to support drug discovery programs. Our cost-efficient standardized and customized assays per client's requirement for ADME parameters will help strengthen your ability to meet your drug discovery and pre-clinical goals. Our ADME capabilities include:


DMPK Screening Services


 •In vitro (liver microsomes/S9/hepatocytes) and in vivo (rodents/non-rodents/primates) metabolite profiling and identification

•Microsomal/S9/hepatocyte/plasma/intestine fluid stability characterization
•Plasma protein binding (RED/HTD) and blood/plasma ratio determination
•Caco-2 permeability, transporter and BBB evaluation
•CYP inhibition (reversible and TDI)/phenotyping/induction assessment
•Expedited discovery screening

Metabolite Identification and Profiling

  • In Vitro Metabolism: Liver Microsomes, Hepatocytes, S9, and Recombinant Enzymes
  • In Vivo Metabolism: plasma, blood, urine and feces
  • Small Molecules and Peptides
  • UPLC with LC/Orbitrap Mass Spectrometer
  • Structural Elucidation


Preclinical Services


Preclinical services are available for rodents, non-rodents, and primates.


•In vivo ADME: PK, tissue distribution, metabolism/excretion, and CSF penetration •Efficacy assays/models, exploratory toxicity studies, and PK/PD modeling •IND-enabling DMPK package study
 

 

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