PHARMout offers ADME (Absorption, Distribution, Metabolism, Excretion) services to provide fast and improved decision making for our clients to support drug discovery programs. Our cost-efficient standardized and customized assays per client's requirement for ADME parameters will help strengthen your ability to meet your drug discovery and pre-clinical goals. Our ADME capabilities include:
DMPK Screening Services
•In vitro (liver microsomes/S9/hepatocytes) and in vivo (rodents/non-rodents/primates) metabolite profiling and identification
Metabolite Identification and Profiling
- In Vitro Metabolism: Liver Microsomes, Hepatocytes, S9, and Recombinant Enzymes
- In Vivo Metabolism: plasma, blood, urine and feces
- Small Molecules and Peptides
- UPLC with LC/Orbitrap Mass Spectrometer
- Structural Elucidation
Preclinical services are available for rodents, non-rodents, and primates.
•In vivo ADME: PK, tissue distribution, metabolism/excretion, and CSF penetration •Efficacy assays/models, exploratory toxicity studies, and PK/PD modeling •IND-enabling DMPK package study
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